kwills88:

Gollum Covers Taylor Swift

I am completely losing my shit over this.

sexgenderbody:

best fucking thing ever

agnesanutter:

canyousonicme:

aikainkauna:

“How did you do that?”

“Disgracefully.”

I ship River and EVERYTHING

neurosciencestuff:

Drugs found to both prevent and treat Alzheimer’s disease in mice

Researchers at USC have found that a class of pharmaceuticals can both prevent and treat Alzheimer’s Disease in mice.

The drugs, known as “TSPO ligands,” are currently used for certain types of neuroimaging.

“We looked at the effects of TSPO ligand in young adult mice when pathology was at an early stage, and in aged mice when pathology was quite severe,” said lead researcher Christian Pike of the USC Davis School of Gerontology. “TSPO ligand reduced measures of pathology and improved behavior at both ages.”

The team’s findings were published online by the Journal of Neuroscience on May 15. Pike’s coauthors include USC postdoctoral scientists Anna M. Barron, Anusha Jayaraman and Joo-Won Lee; as well as Donatella Caruso and Roberto C. Melcangi of the University of Milan and Luis M. Garcia-Segura of the Instituto Cajal in Spain.

The most surprising finding for Pike and his team was the effect of TSPO ligand in the aged mice. Four treatments—once per week over four weeks—in older mice resulted in a significant decrease of Alzheimer’s-related symptoms and improvements in memory – meaning that TSPO ligands may actually reverse some elements of Alzheimer’s disease.

“Our data suggests the possibility of drugs that can prevent and treat Alzheimer’s,” Pike said. “It’s just mouse data, but extremely encouraging mouse data. There is a strong possibility that TSPO ligands similar to the ones used in our study could be evaluated for therapeutic efficacy in Alzheimer’s patients within the next few years.”

Next, the team will next focus on understanding how TSPO ligands reduce Alzheimer’s disease pathology. Building on the established knowledge that TSPO ligands can reduce inflammation—shielding nerve cells from injury and increasing the production of neuroactive hormones in the brain—the team will study which of these actions is the most significant in fighting Alzheimer’s disease so they can develop newer TSPO ligands accordingly.

so-treu:

onregelmatig:

Fifth Element Fashion

Gaultier <3

irishcrookshanks:

Quotes via the Everyday Sexism project.

So much rage right now.

Is that the honey badger? If so I’m not surprised they ran.

veganemelda:

panic-at-the-order-of-the-tardis:

 

Your day just got better and you’re welcome.

special-snowflake-hall-of-fame:

reactionaryhater:

privilegedenyingfeministcunt:

n-wordjim:

privilegedenyingfeministcunt:

here-lies-andalusia:

bearsimdisappointedin:

you know whats worse than tumbears? 

redditbears.

On one of the internet’s most popular, and notorious, sites, a new community is bringing together White gay men with old fashioned tastes internalized homophobia and a penchant for misogyny.

I fixed it.

Mind elaborating on why the mentioned community has internalized homophobia and misogynistic attitudes?

Gay men don’t like sports: nobody can tell them what they can and cannot like.
Gay men do like sports: misogynistic, homophobic, racist (somehow).

Apparently if you don’t act like Kurt or Blaine from that abortion Glee, you’re a bad gay. 

Oh, is this that “if you’re a gay man and prefer masculine men/things over feminine men/things, you’re misogynistic/homophobic” crap? 

I have a preference for blonds. Does that mean I’m prejudiced against brunettes and red heads?

Apparently gay men have to act like a certain parody of themselves and ditch everything they like to be accepted by the overdramatic clusterfuck known as the LGBTQ. 

tyleroakley:

zombiegenocidest:

ACCURATE.

e-zekiel:

Adam Young is my favourite celebrity because I think he forgets he’s a celebrity.